What’s inside Metabolica.

Organic brown rice protein concentrate

Dual plant-protein system paired with pea protein to supply all essential amino acids. Lower leucine and methionine content compared to dairy reduces anabolic mTOR drive while preventing muscle wasting. Moderate total protein (~15 g per serving) supports tissue integrity without exceeding the mTOR-activation threshold.

Organic pea protein isolate

Completes the rice protein amino acid profile, delivering sufficient nitrogen for tissue repair with lower lysine and glutamine content than dairy. Avoids casein- and whey-induced IGF-1 elevations that can promote an inadvertently pro-growth state in cancer patients.

Protease · lipase · carbohydrase complex

Enhances digestion and tolerance in compromised GI tracts — a common sequela of chemotherapy and radiation. Improves utilization of the plant-protein matrix and reduces GI distress in patients with chemotherapy-related mucositis.

C8 / C10 caprylic & capric triglycerides

Used exclusively as the fat source. Rapidly absorbed and converted to ketones — do not contribute to adipose storage. Promote mitochondrial efficiency, lower oxidative stress and systemic inflammation, and provide efficient non-glycemic energy for healthy cells while depriving many tumors of preferred glycolytic substrates.

β-hydroxybutyrate (Na¹, K¹, Mg²¹, Ca²¹)

Exogenous ketone substrate providing mild, stable nutritional ketosis without requiring strict carbohydrate restriction. Increases NAD¹/NADH ratio, inhibits HDAC to upregulate stress-resistance genes, and suppresses NLRP3 inflammasome activity to reduce systemic inflammation.

Fructooligosaccharide prebiotic fibre · GI ≈ 1

Low-glycemic prebiotic fiber that stabilizes glycemia and supports Bifidobacterium and Lactobacillus populations via short-chain fatty acid production. Replaces maltodextrin and glucose syrup found in conventional formulas.

Siraitia grosvenorii · zero-glycemic sweetener

Zero-glycemic natural sweetener that does not stimulate insulin secretion and exhibits potential anti-inflammatory properties. Paired with cinnamon and natural vanilla for a pleasant flavor profile — no artificial sweeteners or preservatives.

Isoquinoline alkaloid · natural AMPK activator

Activates AMPK, promoting fat oxidation, mitochondrial biogenesis, and autophagy while indirectly inhibiting mTOR. Suppresses NF-κB and COX-2 activity, improves insulin sensitivity, and reduces pro-inflammatory cytokine load. (Zhang et al., Biochem Pharmacol., 2020)

Cinnamomum verum · polyphenol type-A polymers

Enhances insulin receptor sensitivity and improves glycemic stability during chemotherapy cycles. Suppresses COX-2 and NF-κB inflammatory signaling alongside berberine and ginger.

Zingiber officinale · standardised gingerols

Reduces IL-6 and TNF-α cytokine expression, suppresses NF-κB activity, and provides clinically validated anti-nausea effects — particularly relevant during treatment cycles where gastric mucosal sensitivity is a primary tolerability barrier.

Deglycyrrhizinated Glycyrrhiza glabra

Soothes gastric mucosa and provides demulcent support to irritated mucosal tissues — directly addressing the GI impact of chemotherapy and radiation on rapidly dividing enterocytes.

Physiologic co-factor levels · Se 11 µg · Zn 5 mg

Provided at optimal co-factor levels for antioxidant and DNA-repair enzymes (SOD, GPx). Magnesium and zinc balance insulin sensitivity. All delivered at physiologic — not pharmacologic — quantities to avoid overstimulating growth or oxidative pathways.

Vitamins A, C, D, E, K · ∼50% DV · B12 at 2.4 µg

Targeted at approximately 50% of daily value — supporting antioxidant systems without redox imbalance. High-dose antioxidants during active treatment are intentionally avoided. B12 limited to 2.4 µg (physiologic) to avoid angiogenic signaling.

Not added · pro-angiogenic risk factors

Copper is a known cofactor in angiogenesis and tumor invasion; iron can amplify oxidative stress and feed tumor proliferation. Iron limited to 0.8 mg versus 8–10 mg in Ensure/Boost; copper not added at any level.

Allergen-free · no artificial sweeteners or preservatives

Casein and whey are potent mTOR activators and the primary protein source in Ensure® and Boost®. Maltodextrin carries a glycemic index above 85. All have been removed entirely from the Metabolica formula.